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Journal of clinical oncology skip to main page content search go advanced search ⻠user name password sign in home search browse by topic archive early release podcasts meeting abstracts resources alerts advertisement ⩠2011 by american society of clinical oncology r1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory ewing sarcoma family of tumors: results of a phase ii sarcoma alliance for research through collaboration study alberto s. Pappo , shreyaskumar r. Patel , john crowley , denise k. Reinke , klaus-peter kuenkele , sant p. Chawla , guy c. Toner , robert g. Maki , paul a. Meyers , rashmi chugh , kristen n. Ganjoo , scott m. Schuetze , heribert juergens , michael g. Leahy , birgit geoerger , robert s. Benjamin , lee j. Helman and laurence h. Baker ↓ alberto s. Pappo, st jude children's research hospital, memphis, tn; shreyaskumar r. Patel and robert s. Benjamin, md anderson cancer center, houston, tx; john crowley, cancer research and biostatistics, seattle, wa; denise k. Reinke, sarcoma alliance for research through collaboration; rashmi chugh, scott m. Schuetze, and laurence h. Baker, university of michigan, ann arbor, mi; klaus-peter kuenkele, roche, penzberg; heribert juergens, university children's hospital, muenster, germany; sant p. real viagra for sale cheap generic viagra buy viagra in the united states viagra for sale cheap generic viagra viagra without a doctor prescription buy generic viagra cheap viagra cheap generic viagra Chawla, sarcoma oncology, santa monica; kristen n. Ganjoo, stanford university, stanford, ca; guy c. Toner, peter maccallum cancer centre, victoria, australia; robert g. Maki and paul a. Meyers, memorial sloan-kettering cancer center, new york, ny; michael g. Leahy, christie hospital national health service foundation trust, manchester, united kingdom; birgit geoerger, institut gustave roussy, villejuif, france; and lee j. Helman, national cancer institute, bethesda, md. Corresponding author: laurence h. Baker, do, 24 frank lloyd wright dr, room lobby a 3400, ann arbor, mi 48105-5731; e-mail: bakerl{at}umich. Edu. Abstract purpose the type 1 insulin-like growth factor 1 receptor (igf-1r) has been implicated in the pathogenesis of the ewing sarcoma family of tumors (esft). We conducted a multicenter phase ii study of the fully human igf-1r monoclonal antibody r1507 in patients with recurrent or refractory esft. Patients and methods patients ≥ 2 years of age with refractory or recurrent esft received r1507 at doses of 9 mg/kg intravenously one a week or 27 mg/kg intravenously every three weeks. Response was measured by using who criteria. Tumor ima.